If you really feel well as higher blood pressure could not display any kind of signs, proceed taking Cozaar even. Inform your medical professional regarding all medicines you utilize, and also those you start or quit making use of during your therapy with Cozaar, especially. High blood stress usually has no signs and symptoms. In multiple-dose studies in hypertensive individuals, there were no noteworthy impacts on kidney or systemic prostaglandin attentions, fasting triglycerides, complete cholesterol or HDL-cholesterol or fasting glucose attentions.
Both losartan and also its principal energetic metabolite do not exhibit any partial agonist activity at the AT1 receptor and also have much better fondness (regarding 1000-fold) for the AT1 receptor compared to for the AT2 receptor. A rather greater interaction (about 40 % reduction in the AUC of energetic metabolite and also around 30 % decrease in the AUC of losartan) has been reported with rifampin. There is no pharmacokinetic communication between losartan and hydrochlorothiazide. A meal reduces absorption of losartan and reduces its Cmax however has only small results on losartan AUC or on the AUC of the metabolite (concerning 10 % minimized).